Publication Highlight: Identification and molecular characterization of M. bovis DNA in GeneXpert® MTB/RIF ultra-positive, culture-negative sputum from a rural community in South Africa
A new study by GenPath Africa consortium members Wynand Goosen, Michele Miller, Rob Warren, Tanya Kerr and Elizabeth Streicher from Stellenbosch University shows there is a high risk of Mycobacterium bovis (M. bovis) spreading from animals to humans in rural South Africa.
What is this publication about?
Using advanced methods of genomic testing and analysis, researchers investigated the presence of M. bovis, a type of bacteria that causes tuberculosis, in sputum samples of people living near the Hluhluwe-iMfolozi Park. The results show that M.bovis was present in several samples, meaning that tuberculosis poses a serious threat to public health in the area.
Why is this important?
This study shows how important advanced and more accurate testing methods are when gathering data on the spread of tuberculosis, especially in regions where wildlife, livestock, and humans interact closely. By sharing these results, researchers are highlighting the importance of close monitoring of the disease and are making crucial data available that will help protect the health of animal and human populations in at-risk areas.
How can it make a difference?
Heightened genomic surveillance can strengthen public health measures against tuberculosis in the future. In addition to close monitoring, this study also strongly advocates for a “One Health” approach, which combines veterinary, wildlife and public health efforts in the fight against tuberculosis. Such comprehensive measures can ensure the well-being of all species in the region and help mitigate the risk of tuberculosis spreading further.
Wynand J. Goosen, Sashen Moodley, Giovanni Ghielmetti, Yumna Moosa, Thando Zulu, Theresa Smit, Vukuzazi Team, Leanie Kleynhans, Tanya J. Kerr, Elizabeth M. Streicher, Willem A. Hanekom, Robin M. Warren, Emily B. Wong, Michele A. Miller. “Identification and molecular characterization of Mycobacterium bovis DNA in GeneXpert® MTB/RIF ultra-positive, culture-negative sputum from a rural community in South Africa,” One Health, 18, 100702, June 2024 (available online March 2024), doi: 10.1016/j.onehlt.2024.100702
